IEEE Transaction on Emerging Topics in Computing (TETC) seeks original manuscripts for a Special Issue/Section on Coordination in Large-Scale Socio-Technical Systems scheduled to appear in the Second Issue of 2015.The massive diffusion of networked ICT devices, increasingly entangled with our physical and social world, is leading to the emergence of large-scale distributed computing systems. These can provide us with a variety of innovative service and new functionalities, once we understand how to direct and coordinate their activities. You can consider sensor/actuator networks; robot swarms; platforms for collective sensing and actions; platforms for global collaboration and production. All of these, to be of some use, require the capability of effectively coordinating the activities of a very large number (up to the millions) of heterogeneous components, such as humans, software agents, robots, and generic ICT devices. And this in spite of components that are: situated in dynamic and unpredictable environments; inherently context-aware in their interaction; inherently autonomous; and, thus, practically impossible to be controlled at the individual level.